Initially a professor of Immunology in the French Nancy University Hospital Immunology Laboratory, Dr. Marie C. Bene developed a deep interest in flow cytometry immunophenotyping when monoclonal antibodies developed as laboratory reagents. This led her to co-found the European Group for Immunophenotyping of Leukemias (EGIL) then become head of the European LeukmiaNet WP10 on morphological and cytometric diagnosis of leukemias. She then applied and was retained as head of the EHA (European Hematology Association) Scientific Working Group on Haematological Diagnosis. Meanwhile, from September 2012 to September 2022, Marie became head of Nantes University Hospital Hematology Laboratory (routine CBC and haemostasis assays, morphology, flow cytometry, cytogenetic and molecular analyses as well as cell-bank). More recently she developed interest in IA-assisted unsupervised FCM analyses.